LSD

LSD (lysergic acid diethylamide) is one of the major drugs
making up the hallucinogen class. LSD was discovered in 1938
and is one of the most potent mood-changing chemicals. It
is manufactured from lysergic acid, which is found in ergot,
a fungus that grows on rye and other grains.
LSD, commonly referred to as "acid," is sold on
the street in tablets, capsules, and, occasionally, liquid
form. It is odorless, colorless, and has a slightly bitter
taste and is usually taken by mouth. Often LSD is added to
absorbent paper, such as blotter paper, and divided into small
decorated squares, with each square representing one dose.
The Drug Enforcement Administration reports that the strength
of LSD samples obtained currently from illicit sources ranges
from 20 to 80 micrograms of LSD per dose. This is considerably
less than the levels reported during the 1960s and early 1970s,
when the dosage ranged from 100 to 200 micrograms, or higher,
per unit.
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The effects of LSD are unpredictable. See hallucinogens. They depend on the amount
taken; the user's personality, mood, and expectations; and
the surroundings in which the drug is used. Usually, the user
feels the first effects of the drug 30 to 90 minutes after
taking it. The physical effects include dilated pupils, higher
body temperature, increased heart rate and blood pressure,
sweating, loss of appetite, sleeplessness, dry mouth, and
tremors.
Sensations and feelings change much more dramatically than
the physical signs. The user may feel several different emotions
at once or swing rapidly from one emotion to another. If taken
in a large enough dose, the drug produces delusions and visual
hallucinations. The user's sense of time and self changes.
Sensations may seem to "cross over," giving the
user the feeling of hearing colors and seeing sounds. These
changes can be frightening and can cause panic.
Users refer to their experience with LSD as a "trip"
and to acute adverse reactions as a "bad trip."
These experiences are long - typically they begin to clear
after about 12 hours.
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Some LSD users experience severe, terrifying thoughts and
feelings, fear of losing control, fear of insanity and death,
and despair while using LSD. Some fatal accidents have occurred
during states of LSD intoxication.
Many LSD users experience flashbacks, recurrence of certain
aspects of a person's experience, without the user having
taken the drug again. A flashback occurs suddenly, often without
warning, and may occur within a few days or more than a year
after LSD use. Flashbacks usually occur in people who use
hallucinogens chronically or have an underlying personality
problem; however, otherwise healthy people who use LSD occasionally
may also have flashbacks. Bad trips and flashbacks are only
part of the risks of LSD use. LSD users may manifest relatively
long-lasting psychoses, such as schizophrenia or severe depression.
It is difficult to determine the extent and mechanism of the
LSD involvement in these illnesses.
Most users of LSD voluntarily decrease or stop its use over
time. LSD is not considered an addictive drug since it does
not produce compulsive drug-seeking behavior as do cocaine,
amphetamine, heroin, alcohol, and nicotine. However, like
many of the addictive drugs, LSD produces tolerance, so some
users who take the drug repeatedly must take progressively
higher doses to achieve the state of intoxication that they
had previously achieved. This is an extremely dangerous practice,
given the unpredictability of the drug. NIDA is funding studies
that focus on the neurochemical and behavioral properties
of LSD. This research will provide a greater understanding
of the mechanisms of action of the drug.
Extent of Use
Monitoring the Future Study (MTF)*
Since 1975, MTF researchers have annually surveyed almost
17,000 high school seniors nationwide to determine trends
in drug use and to measure attitudes and beliefs about drug
abuse. Over the past 2 years, the percentage of seniors who
have used LSD has remained relatively stable. Between 1975
and 1997, the lowest lifetime use of LSD was reported by the
class of 1986, when 7.2 percent of seniors reported using
LSD at least once in their lives. In 1997, 13.6 percent of
seniors had experimented with LSD at least once in their lifetimes.
The percentage of seniors reporting use of LSD in the past
year nearly doubled from a low of 4.4 percent in 1985 to 8.4
percent in 1997.
In 1997, 34.7 percent of seniors perceived great risk in using
LSD once or twice, and 76.6 percent said they saw great risk
in using LSD regularly. More than 80 percent of seniors disapproved
of people trying LSD once or twice, and almost 93 percent
disapproved of people taking LSD regularly.
Almost 51 percent of seniors said it would have been fairly
easy or very easy for them to get LSD if they had wanted it.
LSD Use by Students, 1997:
Monitoring the Future Study
8th Graders 10th Graders 12th Graders
Ever Used 4.7% 9.5% 13.6%
Used in Past Year 3.2 6.7 8.4
Used in Past Month 1.5 2.8 3.1
National Household Survey on Drug Abuse (NHSDA)**
NHSDA reports the nature and extent of drug use among the
American household popula tion aged 12 and older. In the 1996
NHSDA estimates, the percentage of the population aged 12
and older who had ever used LSD (the lifetime prevalence rate)
had increased to 7.7 percent from 6.0 percent in 1988. Among
youths 12 to 17 years old, the 1996 LSD lifetime prevalence
rate was 4.3 percent, and for those aged 18 to 25, the rate
was 13.9 percent. The rate for past-year use of LSD among
the population ages 12 and older was 1 percent in 1996. Past-year
prevalence was highest among the age groups 12 to 17 (2.8
percent) and 18 to 25 (4.6 percent). The rate of current LSD
use in 1996 for those aged 18 to 25 was 0.9 percent, and it
was 0.8 percent for 12- to 17-year-old youths.
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